Substitution at R3 that has a halogen or alkoxy group (74f–74i) triggered a slight rise in cellular potency Using the halide analogs (74g–h) showing best the potency from the group. Further optimization led to the invention of 74i–j, with 74k as by far the most Energetic compound in the sequence https://indazole-products97531.dailyblogzz.com/31975257/the-greatest-guide-to-indazole-n-oxide