You will find a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to decrease afferent agony transmission and generate analgesia. As a result, medication like clonidine that concentrate on alpha-two receptors can affect the transmission of soreness. Applies to clonidine: https://www.proleviate.com/post/the-new-pain-killer-conolidine