There's a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lower afferent agony transmission and make analgesia. Consequently, medication like clonidine that target alpha-two receptors can impact the transmission of pain. This document will not comprise all feasible interactions. https://socialrus.com/story20504854/new-step-by-step-map-for-onolidine