Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. Not like opioids, which bind to µ-opioid receptors while in the central anxious process, conolidine modulates alternate molecular targets. A Science Innovations analyze identified that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://zanewvnco.uzblog.net/little-known-facts-about-conoldine-alternative-natural-pain-relief-51809759